Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 4/20 | 0.47 |
| ▸ | KLK1 | P06870 | 2/20 | 0.47 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.47 |
| ▸ | TMPRSS15 | P98073 | 7/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008667 | 0.79 | PRSS1 (0.47) | PRSS1KLK1TMPRSS2TMPRSS15PRSS2 | |
| SCHEMBL20008691 | 0.78 | PRSS1 (0.40) | PRSS1KLK1TMPRSS2TMPRSS15SRD5A2 | |
| SCHEMBL20008687 | 0.70 | PRSS1 (0.44) | PRSS1KLK1TMPRSS2TMPRSS15PRSS2 | |
| SCHEMBL20008674 | 0.68 | PRSS1 (0.42) | PRSS1KLK1TMPRSS2TMPRSS15PRSS2 | |
| SCHEMBL20008683 | 0.68 | PRSS1 (0.45) | PRSS1KLK1TMPRSS2TMPRSS15PRSS2 | |
| SCHEMBL20008686 | 0.68 | TMPRSS15 (0.47) | PRSS1KLK1TMPRSS2TMPRSS15NR1H4 | |
| SCHEMBL20008672 | 0.68 | KDM4E (0.40) | PRSS1KLK1TMPRSS2TMPRSS15PRSS2 | |
| SCHEMBL8660216 | 0.68 | PRSS1 (0.64) | PRSS1KLK1TMPRSS2TMPRSS15SRD5A2 | |
| SCHEMBL17236361 | 0.67 | MAPT (0.64) | MAPTTDP1L3MBTL1 | |
| SCHEMBL6721103 | 0.67 | MAPT (0.55) | PRSS1TMPRSS15MAPTTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180085366-A1 | OPIOID COMPOSITIONS RESISTANT TO OVERDOSE AND ABUSE | ELYSIUM THERAPEUTICS, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180085366-A1 | OPIOID COMPOSITIONS RESISTANT TO OVERDOSE AND ABUSE | OPRM1, OPRK1, OPRD1 | PRSS1 952/4885KLK1 3383/4885TMPRSS2 588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.