Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.35 |
| ▸ | PARG | Q86W56 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | NMT1 | P30419 | 2/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20011175 | 0.80 | PARG (0.31) | PARGTNF | |
| SCHEMBL20011542 | 0.73 | TNF (0.35) | TNF | |
| SCHEMBL4557788 | 0.72 | TNF (0.46) | MAPTTNF | |
| SCHEMBL18255777 | 0.72 | ADORA2B (0.58) | TRPA1TNF | |
| SCHEMBL17619749 | 0.72 | TRPA1 (0.57) | TRPA1GRIN1GRIN2BPARGGABRA5 | |
| SCHEMBL20011328 | 0.72 | PARG (0.33) | PARG | |
| SCHEMBL17619786 | 0.70 | TRPA1 (0.58) | TRPA1GRIN1GRIN2BPARG | |
| SCHEMBL20011548 | 0.69 | PARG (0.33) | PARG | |
| SCHEMBL18256158 | 0.69 | TRPA1 (0.52) | TRPA1MAPTTNF | |
| SCHEMBL20011545 | 0.68 | PARG (0.41) | GRIN1GRIN2BPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299371-A1 | HYDROXYL PURINE COMPOUNDS AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-03-28 | — | — | EP | disclosed |