Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFB | P00751 | 8/20 | 0.58 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28210594 | 0.83 | CFB (0.56) | CFBCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL16400851 | 0.77 | CFB (0.46) | CFBKDM1ARIPK1 | |
| SCHEMBL20011760 | 0.73 | CFB (0.43) | CFBKDM1ARIPK1 | |
| SCHEMBL28065026 | 0.72 | RIPK1 (0.44) | CFBKDM1ARIPK1 | |
| SCHEMBL16409384 | 0.72 | RIPK1 (0.44) | CFBRIPK1 | |
| SCHEMBL12232914 | 0.67 | AKR1C3 (0.43) | CFB | |
| SCHEMBL28119684 | 0.67 | CFB (0.30) | CFB | |
| SCHEMBL28209964 | 0.67 | KDM1A (0.43) | CFBCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3609864 | 0.65 | CHRNB2 (0.50) | CFBCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL30668566 | 0.65 | SLC6A9 (0.45) | CFBCHRNB2CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579444-B | Piperidinylindole derivatives and their use as complement factor B inhibitors | 诺华股份有限公司 | 2018-05-01 | — | — | CN | disclosed |