Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12125282 | 0.87 | ALDH1A1 (0.68) | ALDH1A1KMT2ALMNAMAPTHTT | |
| SCHEMBL12123647 | 0.83 | ALDH1A1 (0.65) | ALDH1A1KMT2AGFERLMNAMAPT | |
| SCHEMBL5365088 | 0.82 | SIGMAR1 (0.69) | ALDH1A1KMT2ALMNAHTTCHRM4 | |
| SCHEMBL7350313 | 0.82 | ALDH1A1 (0.68) | ALDH1A1KMT2AGFERLMNAMAPT | |
| SCHEMBL11755100 | 0.81 | ALDH1A1 (0.71) | ALDH1A1KMT2AGFERLMNAMAPT | |
| SCHEMBL8001854 | 0.80 | ALDH1A1 (0.70) | ALDH1A1KMT2AGFERLMNAMAPT | |
| SCHEMBL26135918 | 0.79 | MMP1 (0.76) | ALDH1A1MAPTHRH3MMP1 | |
| SCHEMBL13069210 | 0.79 | ALDH1A1 (0.73) | ALDH1A1KMT2AGFERLMNAMAPT | |
| SCHEMBL12267314 | 0.79 | ALDH1A1 (0.78) | ALDH1A1KMT2AGFERLMNAMAPT | |
| SCHEMBL1140551 | 0.79 | ALDH1A1 (0.68) | ALDH1A1KMT2AGFERLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11198679-B2 | Method of treating or preventing Ras-mediated diseases | ADT PHARMACEUTICALS, LLC (US) | 2021-12-14 | — | — | US | disclosed |
| US-20200223817-A1 | METHOD OF TREATING OR PREVENTING RAS-MEDIATED DISEASES | ADT PHARMACEUTICALS, LLC (US) | 2020-07-16 | — | — | US | disclosed |
| US-9931315-B2 | Method of selectively inhibiting Ras-mediated tumor growth in humans | ADT PHARMACEUTICALS, INC. (US) | 2018-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11198679-B2 | Method of treating or preventing Ras-mediated diseases | KRAS, NRAS, HRAS | ALDH1A1 1984/4885KMT2A 2337/4885GFER 1706/4885 |
| US-20200223817-A1 | METHOD OF TREATING OR PREVENTING RAS-MEDIATED DISEASES | KRAS, NRAS, HRAS | ALDH1A1 1984/4885KMT2A 2337/4885GFER 1706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.