Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.44 |
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | CA3 | P07451 | 3/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TYR | P14679 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.44 |
| ▸ | CA5A | P35218 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22043774 | 0.89 | NOS3 (0.48) | KDM1ALMNAMAPTHSD17B10CYP3A4 | |
| SCHEMBL22815269 | 0.82 | KDM1A (0.48) | KDM1ALMNAMAPTHSD17B10CYP3A4 | |
| SCHEMBL12873713 | 0.81 | KDM1A (0.76) | KDM1ALMNAMAPTHSD17B10CYP3A4 | |
| SCHEMBL771386 | 0.81 | KDM1A (0.76) | KDM1ALMNAMAPTHSD17B10CYP3A4 | |
| SCHEMBL1187298 | 0.81 | KDM1A (0.76) | KDM1ALMNAMAPTHSD17B10CYP3A4 | |
| SCHEMBL14393378 | 0.79 | KDM1A (0.50) | KDM1ALMNAMAPTHSD17B10CYP3A4 | |
| SCHEMBL21553910 | 0.78 | PLAU (0.52) | LMNAMAPTHSD17B10CYP3A4HIF1A | |
| SCHEMBL7717290 | 0.75 | LMNA (0.39) | KDM1ALMNAHSD17B10HIF1AMEN1 | |
| SCHEMBL18938347 | 0.74 | KMT2A (0.61) | MAPTHSD17B10CYP3A4HIF1AMEN1 | |
| SCHEMBL9628010 | 0.74 | KDM1A (0.46) | KDM1ALMNAMAPTHSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4245744-A2 | CHEMICALLY CLEAVABLE GROUP | Tagworks Pharmaceuticals B.V. (NL) | 2023-09-20 | — | — | EP | disclosed |
| US-20210162060-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2021-06-03 | — | — | US | disclosed |
| US-10967069-B2 | Bio-orthogonal drug activation | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2021-04-06 | — | — | US | disclosed |
| US-10927139-B2 | Chemically cleavable group | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2021-02-23 | — | — | US | disclosed |
| US-20190336612-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2019-11-07 | — | — | US | disclosed |
| US-9931408-B2 | Bio-orthogonal drug activation | KONINKLIJKE PHILIPS N.V. (NL) | 2018-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10967069-B2 | Bio-orthogonal drug activation | JMJD7, KIT, PAICS | KDM1A 1573/4885LMNA 4539/4885MAPT 2466/4885 |
| US-20210162060-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | JMJD7, KIT, PAICS | KDM1A 1573/4885LMNA 4539/4885MAPT 2466/4885 |
| US-10927139-B2 | Chemically cleavable group | SQLE, CTRL, ENO1 | KDM1A 4425/4885LMNA 1188/4885MAPT 2604/4885 |
| US-20190336612-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | JMJD7, KIT, PAICS | KDM1A 1573/4885LMNA 4539/4885MAPT 2466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.