Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 5/20 | 0.36 |
| ▸ | GABRD | O14764 | 5/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.36 |
| ▸ | GABRE | P78334 | 5/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 5/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003583 | 0.81 | MAPT (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6976085 | 0.79 | KDR (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7480496 | 0.77 | GABRP (0.40) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7239468 | 0.77 | KDR (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL239495 | 0.76 | GABRB3 (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2138287 | 0.76 | GABRP (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2003545 | 0.75 | MAPT (0.33) | MAPT | |
| SCHEMBL2003544 | 0.75 | MAPT (0.33) | MAPT | |
| SCHEMBL7489890 | 0.75 | KDR (0.40) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Ammonia Solution, Strong SCHEMBL8425567 | 0.75 | GABRB3 (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084486-B2 | Substituted arylpyrazoles | PFIZER LIMITED (GB) | 2011-12-27 | — | — | US | disclosed |
| US-20110196011-A1 | SUBSTITUTED ARYLPYRAZOLES | PFIZER LIMITED (GB) | 2011-08-11 | — | — | US | disclosed |
| US-7960426-B2 | Substituted arylpyrazoles | PFIZER LIMITED (GB) | 2011-06-14 | — | — | US | disclosed |
| US-7902232-B2 | Substituted arylpyrazoles | PFIZER LIMITED (GB) | 2011-03-08 | — | — | US | disclosed |
| US-7803832-B2 | N-(1-arylpyrazol-4L)sulfonamides and their use as parasiticides | PFIZER INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-7687533-B2 | N-(1-arylpyrazol-4l) sulfonamides and their use as parasiticides | PFIZER INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-20100075956-A1 | N-(1-ARYLPYRAZOL-4L)SULFONAMIDES AND THEIR USE AS PARASITICIDES | PFIZER INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20090312371-A1 | SUBSTITUTED ARYLPYRAZOLES | PFIZER LIMITED (GB) | 2009-12-17 | — | — | US | disclosed |
| US-20090137524-A1 | SUBSTITUTED ARYLPYRAZOLES | ZOETIS SERVICES LLC | 2009-05-28 | — | — | US | disclosed |
| US-7514464-B2 | Substituted arylpyrazoles | PFIZER LIMITED (GB) | 2009-04-07 | — | — | US | disclosed |
| US-6372774-B1 | THESE COMPOUNDS POSSESS ARTHROPODICIDAL, PLANT NEMATOCIDAL, ANTHELMINTIC AND ANTI-PROTOZOAL PROPERTIES | RHONE-POULENC AGRICULTURE LTD. (GB) | 2002-04-16 | — | — | US | disclosed |
| EP-0967206-A1 | Derivatives of N-phenylpyrazoles | RHONE POULENC AGRICULTURE LTD. (GB) | 1999-12-29 | — | — | EP | disclosed |
| US-5916618-A | PESTICIDE FOR MEDICATED FEEDSTUFF, DIETARY CONCENTRATE OR SUPPLEMENT | RHONE-POULENC AGRICULTURE LTD. (GB) | 1999-06-29 | — | — | US | disclosed |
| US-5714191-A | PESTICIDES USED IN MEDICATED FEEDSTUFF, MINERAL SALT LICK OR EDIBLE BAIT | RHONE-POULENC AGRICULTURE LTD. (GB) | 1998-02-03 | — | — | US | disclosed |
| US-5608077-A | INSECTICIDES, NEMATOCIDES, ANTHELMINTICS, ANTIPROTOZOA AGENTS | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-03-04 | — | — | US | disclosed |
| US-5547974-A | INSECTICIDES, NEMATOCIDES, ANTHELMINTICS | RHONE-POULENC AGRICULTURE LTD. (GB) | 1996-08-20 | — | — | US | disclosed |
| EP-0418016-B1 | N-phenylpyrazole derivatives as insecticides | RHONE POULENC AGRICULTURE (GB) | 1995-05-03 | — | — | EP | disclosed |
| US-5232940-A | Controlling insects, plant nematodes, helminths, protozoa | BASF AGRO B.V., ARNHEM (NL), WADENSWIL-BRANCH (CH) | 1993-08-03 | — | — | US | disclosed |
| EP-0418016-A1 | N-phenylpyrazole derivatives as insecticides | RHONE-POULENC AGRICULTURE LTD. (GB) | 1991-03-20 | — | — | EP | disclosed |
| EP-0295117-A1 | Derivatives of N-phenylpyrazoles | RHONE-POULENC AGRICULTURE LIMITED (GB) | 1988-12-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137524-A1 | SUBSTITUTED ARYLPYRAZOLES | CYP4X1, EPX, CYP2C9 | GABRP 1847/4885GABRD 2228/4885GABRA1 1260/4885 |
| US-20110196011-A1 | SUBSTITUTED ARYLPYRAZOLES | CYP4X1, EPX, CYP2C9 | GABRP 1847/4885GABRD 2228/4885GABRA1 1260/4885 |
| US-20100075956-A1 | N-(1-ARYLPYRAZOL-4L)SULFONAMIDES AND THEIR USE AS PARASITICIDES | ARSA, STS, SULT1E1 | GABRP 1611/4885GABRD 2916/4885GABRA1 1754/4885 |
| US-20090312371-A1 | SUBSTITUTED ARYLPYRAZOLES | CYP3A43, CYP3A4, CYP4X1 | GABRP 675/4885GABRD 1285/4885GABRA1 648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.