Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 12/20 | 0.41 |
| ▸ | GABRD | O14764 | 12/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 12/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 12/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 12/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 12/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 12/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 12/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 12/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 12/20 | 0.41 |
| ▸ | GABRE | P78334 | 12/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 12/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 12/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 12/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 12/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239495 | 0.82 | GABRB3 (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2002008 | 0.81 | GABRP (0.36) | MAPTMAPK1RECQLL3MBTL1GABRP | |
| Ammonia Solution, Strong SCHEMBL8425567 | 0.81 | GABRB3 (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6976085 | 0.79 | KDR (0.51) | MAPTMAPK1L3MBTL1GABRPGABRD | |
| SCHEMBL7707192 | 0.79 | GABRP (0.51) | MAPTMAPK1RECQLL3MBTL1GABRP | |
| SCHEMBL2138287 | 0.78 | GABRP (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7713381 | 0.78 | GABRP (0.50) | MAPTMAPK1RECQLL3MBTL1GABRP | |
| SCHEMBL30831882 | 0.77 | GABRA2 (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1751331 | 0.77 | GABRA2 (0.47) | MAPTMAPK1RECQLL3MBTL1GABRP | |
| SCHEMBL7715389 | 0.77 | GABRP (0.52) | MAPTMAPK1RECQLL3MBTL1GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9339033-B2 | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | MERIAL, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| EP-2035390-B1 | 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | MERIAL INC (US) | 2015-12-09 | — | — | EP | disclosed |
| US-20150133506-A1 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | AVENTIS AGRICULTURE (FR) | 2015-05-14 | — | — | US | disclosed |
| US-8785372-B2 | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | AVENTIS AGRICULTURE | 2014-07-22 | — | — | US | disclosed |
| US-20130324457-A1 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | AVENTIS AGRICULTURE (FR) | 2013-12-05 | — | — | US | disclosed |
| US-8445519-B2 | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | AVENTIS AGRICULTURE (FR) | 2013-05-21 | — | — | US | disclosed |
| EP-2465851-A1 | 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | Aventis Agriculture (FR) | 2012-06-20 | — | — | EP | disclosed |
| US-8084486-B2 | Substituted arylpyrazoles | PFIZER LIMITED (GB) | 2011-12-27 | — | — | US | disclosed |
| US-20110196011-A1 | SUBSTITUTED ARYLPYRAZOLES | PFIZER LIMITED (GB) | 2011-08-11 | — | — | US | disclosed |
| US-7960426-B2 | Substituted arylpyrazoles | PFIZER LIMITED (GB) | 2011-06-14 | — | — | US | disclosed |
| EP-0967206-A1 | Derivatives of N-phenylpyrazoles | RHONE POULENC AGRICULTURE LTD. (GB) | 1999-12-29 | — | — | EP | disclosed |
| US-5916618-A | PESTICIDE FOR MEDICATED FEEDSTUFF, DIETARY CONCENTRATE OR SUPPLEMENT | RHONE-POULENC AGRICULTURE LTD. (GB) | 1999-06-29 | — | — | US | disclosed |
| EP-0918756-A1 | PARASITICIDAL PYRAZOLES | Pfizer Limited (GB) | 1999-06-02 | — | — | EP | disclosed |
| WO-1998004530-A1 | PARASITICIDAL PYRAZOLES | PFIZER LIMITED (GB) | 1998-02-05 | — | — | WO | disclosed |
| US-5714191-A | PESTICIDES USED IN MEDICATED FEEDSTUFF, MINERAL SALT LICK OR EDIBLE BAIT | RHONE-POULENC AGRICULTURE LTD. (GB) | 1998-02-03 | — | — | US | disclosed |
| US-5608077-A | INSECTICIDES, NEMATOCIDES, ANTHELMINTICS, ANTIPROTOZOA AGENTS | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-03-04 | — | — | US | disclosed |
| US-5547974-A | INSECTICIDES, NEMATOCIDES, ANTHELMINTICS | RHONE-POULENC AGRICULTURE LTD. (GB) | 1996-08-20 | — | — | US | disclosed |
| EP-0418016-B1 | N-phenylpyrazole derivatives as insecticides | RHONE POULENC AGRICULTURE (GB) | 1995-05-03 | — | — | EP | disclosed |
| US-5232940-A | Controlling insects, plant nematodes, helminths, protozoa | BASF AGRO B.V., ARNHEM (NL), WADENSWIL-BRANCH (CH) | 1993-08-03 | — | — | US | disclosed |
| EP-0295117-A1 | Derivatives of N-phenylpyrazoles | RHONE-POULENC AGRICULTURE LIMITED (GB) | 1988-12-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133506-A1 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | CBR3, CBR1, NR5A2 | MAPT 4885/4885MAPK1 1658/4885RECQL 3122/4885 |
| US-20110196011-A1 | SUBSTITUTED ARYLPYRAZOLES | CYP4X1, EPX, CYP2C9 | MAPT 4313/4885MAPK1 2517/4885RECQL 555/4885 |
| US-20130324457-A1 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | CBR3, CBR1, NR5A2 | MAPT 4885/4885MAPK1 1658/4885RECQL 3122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.