Sugi Predict

Sugi Predict / Compounds / SCHEMBL239495

SCHEMBL239495

SCHEMBL239495

N#Cc1cc(N)n(-c2c(Cl)cc(C(F)(F)F)cc2Cl)n1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GABRB3 P28472 19/20 0.60
▸ GABRA2 P47869 17/20 0.60
▸ GABRB2 P47870 17/20 0.60
▸ GABRP O00591 16/20 0.60
▸ GABRD O14764 16/20 0.60
▸ GABRA1 P14867 16/20 0.60
▸ GABRB1 P18505 16/20 0.60
▸ GABRG2 P18507 16/20 0.60
▸ GABRA5 P31644 16/20 0.60
▸ GABRA3 P34903 16/20 0.60
▸ GABRA4 P48169 16/20 0.60
▸ GABRE P78334 16/20 0.60
▸ GABRA6 Q16445 16/20 0.60
▸ GABRG1 Q8N1C3 16/20 0.60
▸ GABRG3 Q99928 16/20 0.60
▸ GABRQ Q9UN88 16/20 0.60
▸ NR1I2 O75469 1/20 0.54
▸ LMNA P02545 1/20 0.54
▸ CYP3A4 P08684 1/20 0.54
▸ SMN1; SMN2 Q16637 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL8425567 0.99 GABRB3 (0.59) GABRB3GABRA2GABRB2GABRPGABRD
Sulfurous Acid SCHEMBL28641882 0.92 GABRA2 (0.57) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL14615157 0.92 GABRB3 (0.55) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL2835184 0.92 GABRA2 (0.52) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL30693085 0.91 GABRB3 (0.51) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL7028502 0.91 GABRB3 (0.51) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL28641880 0.89 GABRA2 (0.54) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL7240189 0.87 GABRA2 (0.47) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL30831882 0.87 GABRA2 (0.45) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL8923472 0.86 GABRA2 (0.47) GABRB3GABRA2GABRB2GABRPGABRD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 389 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122010772-A Rapid conversion method for continuous production of diazonium salt 威海韩孚生化药业有限公司 2026-05-12 — — CN claimed
US-12221421-B2 Process for synthesis of Fipronil GHARDA CHEMICALS LIMITED (IN) 2025-02-11 — — US claimed
CN-115974783-B Preparation method of 5-amino-3-cyano-1- (2, 6-dichloro-4-trifluoromethylphenyl) pyrazole 湖北灵泽医药科技有限公司 2025-01-24 — — CN claimed
CN-117486800-A Synthesis method of fipronil intermediate 浙江埃森化学有限公司 2024-02-02 — — CN claimed
CN-117224536-A Composition and application thereof in preparation of medicines for killing fleas 广州爪爪博士宠物科技有限公司 2023-12-15 — — CN claimed
CN-114181152-B Preparation method of arylpyrazole drug intermediate 中国农业科学院兰州畜牧与兽药研究所 2023-08-22 — — CN claimed
CN-115974783-A Preparation method of 5-amino-3-cyano-1- (2, 6-dichloro-4-trifluoromethylphenyl) pyrazole 湖北灵泽医药科技有限公司 2023-04-18 — — CN claimed
CN-115340554-B Pyrazolopyrimidine compound, preparation method thereof and application of pyrazolopyrimidine compound as fluorescent probe 华南农业大学 2023-04-18 — — CN claimed
CN-115650919-A Method for preparing fipronil from trichloromethyl sulfinyl chloride 华东理工大学 2023-01-31 — — CN claimed
WO-2023279671-A1 METHOD FOR SYNTHESIZING FIPRONIL INTERMEDIATE 浙江海正药业股份有限公司 2023-01-12 — — WO claimed
WO-2008055880-A1 PROCESS FOR THE SULFINYLATION OF A PYRAZOLE DERIVATIVE BASF SE (DE) 2008-05-15 — — WO claimed
WO-2008055877-A1 PROCESS FOR THE SULFINYLATION OF A PYRAZOLE DERIVATIVE BASF SE (DE) 2008-05-15 — — WO claimed
CN-101139322-A Method for preparing 5-amido-1-(2,6-dichlorin-4-trifluoro methylbenzene)-3-cyano pyrazole UNIV ZHEJIANG TECHNOLOGY (CN) 2008-03-12 — — CN claimed
US-6919462-B2 Using 1-aryl-3-cyano-5-aminopyrazole compound BASF AGRO B.V., AMHEM (NL) - WADENSWIL BRANCH (CH) 2005-07-19 — — US claimed
US-6881848-B2 Process for preparing 4-trifluoromethylsulfinylpyrazole derivative BASF Agro B.V. Arnhem (NL), Wädenswil-Branch (CH) 2005-04-19 — — US claimed
US-20040034234-A1 Process for preparing 4-trifluoromethylsulfinylpyrazole derivative BASF AGRO B.V., ARNHEM (NL), WADENSWIL-BRANCH (CH) 2004-02-19 — — US claimed
US-20040030140-A1 Using 1-aryl-3-cyano-5-aminopyrazole compound AVENTIS CROPSCIENCE S.A. (FR) 2004-02-12 — — US claimed
US-6620944-B1 Reacting 2,6-dichloro-4-trifluoromethylphenylhydrazine with chloroacetyl chloride, then halogenating and cyanating to form compounds such as 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoro -methylphenyl)pyrazole AVENTIS CROPSCIENCE S.A. (FR) 2003-09-16 — — US claimed
EP-1331222-A1 Environment friendly reagents and process for halogenoalkylsulfinylation of organic compounds VIRBAC S.A. (FR) 2003-07-30 — — EP claimed
US-6084105-A Processes for preparing pesticidal intermediates RHONE-POULENC AGRO (FR) 2000-07-04 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040034234-A1 Process for preparing 4-trifluoromethylsulfinylpyrazole derivative CYP2F1, CYP4F2, F12 GABRB3 582/4885GABRA2 344/4885GABRB2 296/4885
US-20040030140-A1 Using 1-aryl-3-cyano-5-aminopyrazole compound CYCS, CYC1, KCNH1 GABRB3 1064/4885GABRA2 1631/4885GABRB2 1306/4885
US-12221421-B2 Process for synthesis of Fipronil FIP1L1, PFAS, NPEPPS GABRB3 1083/4885GABRA2 839/4885GABRB2 960/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.