Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 4/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20020909 | 0.84 | KDM4E (0.38) | PRKCIAURKARPS6KB1DYRK1AMAPT | |
| SCHEMBL20021168 | 0.84 | PRKCI (0.37) | PRKCIAURKARPS6KB1DYRK1AMAPT | |
| SCHEMBL3298420 | 0.76 | TYMS (0.45) | PRKCIDYRK1AMAPTRAB9ADYRK2 | |
| SCHEMBL15182506 | 0.72 | FABP4 (0.35) | PRKCIDYRK1AMAPTDYRK2DYRK1B | |
| SCHEMBL20021100 | 0.72 | HPGD (0.44) | PRKCIMAPTNPC1POLBRAB9A | |
| SCHEMBL13736784 | 0.72 | KEAP1 (0.38) | PRKCIAURKARPS6KB1DYRK1ANPC1 | |
| SCHEMBL21662885 | 0.69 | CYP3A4 (0.41) | PRKCIDYRK1AMAPTNPC1RAB9A | |
| SCHEMBL15169189 | 0.67 | MAPK1 (0.31) | PRKCIDYRK1AMAPTNPC1POLB | |
| SCHEMBL10157309 | 0.61 | KDM4E (0.44) | PRKCIDYRK1ANPC1RAB9AKDM4E | |
| SCHEMBL13101720 | 0.61 | ALDH1A1 (0.53) | MAPTPOLBKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588455-B1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES INC (US) | 2018-04-04 | — | — | EP | disclosed |