Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20021160 | 0.84 | PRKCI (0.34) | PRKCIMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL20020909 | 0.84 | KDM4E (0.38) | PRKCIMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL5165673 | 0.78 | KDM4E (0.57) | MAPTKDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL3298420 | 0.76 | TYMS (0.45) | PRKCIMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL15182506 | 0.72 | FABP4 (0.35) | PRKCIMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL20021100 | 0.72 | HPGD (0.44) | PRKCIMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL13736784 | 0.72 | KEAP1 (0.38) | PRKCIKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL1150915 | 0.69 | PARP1 (0.51) | PARP1PNMT | |
| SCHEMBL21662885 | 0.69 | CYP3A4 (0.41) | PRKCIMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL28860523 | 0.68 | PNMT (0.44) | MEN1KMT2APARP1CD274PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588455-B1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES INC (US) | 2018-04-04 | — | — | EP | disclosed |