Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 10/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2008123 | 0.93 | ACHE (0.41) | LMNAALOX5APALOX5CYP3A4CYP2C9 | |
| SCHEMBL2002167 | 0.92 | ALOX5AP (0.43) | LMNAALOX5APALOX5CYP3A4CYP2C9 | |
| SCHEMBL2000474 | 0.91 | LMNA (0.41) | LMNASMN1; SMN2CYP3A4CYP2C9MAPT | |
| SCHEMBL2002746 | 0.91 | F2RL3 (0.37) | LMNASMN1; SMN2ALOX5APALOX5CYP3A4 | |
| SCHEMBL2005115 | 0.90 | ALOX5AP (0.37) | LMNASMN1; SMN2ALOX5APALOX5MAPT | |
| SCHEMBL2011328 | 0.90 | LMNA (0.40) | LMNASMN1; SMN2ALOX5APCYP3A4CYP2C9 | |
| SCHEMBL2008873 | 0.89 | LMNA (0.38) | LMNASMN1; SMN2ALOX5APCYP3A4CYP2C9 | |
| SCHEMBL2004385 | 0.89 | LMNA (0.43) | LMNASMN1; SMN2ALOX5APCYP3A4CYP2C9 | |
| SCHEMBL2003907 | 0.88 | L3MBTL1 (0.41) | LMNASMN1; SMN2CYP3A4CYP2C9MAPT | |
| SCHEMBL2011749 | 0.88 | LMNA (0.38) | LMNASMN1; SMN2ALOX5APMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |