Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8776773 | 0.87 | KMT2A (0.69) | HPGDAPEX1KMT2ATP53GLA | |
| SCHEMBL10649706 | 0.84 | ALDH1A1 (0.62) | HPGDALDH1A1KDM4ESMN1; SMN2APEX1 | |
| SCHEMBL20022705 | 0.84 | APEX1 (0.57) | HPGDALDH1A1KDM4ESMN1; SMN2APEX1 | |
| SCHEMBL1034235 | 0.84 | HPGD (0.72) | HPGDALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL8226871 | 0.83 | APEX1 (0.64) | HPGDALDH1A1HSD17B10SMN1; SMN2APEX1 | |
| SCHEMBL7823453 | 0.83 | APEX1 (0.84) | HPGDALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL15686093 | 0.81 | HPGD (0.68) | HPGDALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL28730014 | 0.81 | HPGD (1.00) | HPGDALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL15686111 | 0.81 | ALDH1A1 (0.68) | HPGDALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL28053365 | 0.81 | HPGD (0.68) | HPGDALDH1A1KDM4EHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180092908-A1 | SMALL MOLECULE OXIDIZERS OF PDI AND THEIR USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180092908-A1 | SMALL MOLECULE OXIDIZERS OF PDI AND THEIR USE | PDIA5, PDIA4, PDIA6 | HPGD 87/4885ALDH1A1 1489/4885KDM4E 4750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.