Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 1/20 | 0.69 |
| ▸ | TGM2 | P21980 | 4/20 | 0.52 |
| ▸ | DTYMK | P23919 | 1/20 | 0.51 |
| ▸ | KAT2B | Q92831 | 7/20 | 0.47 |
| ▸ | EP300 | Q09472 | 3/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.46 |
| ▸ | KAT2A | Q92830 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21996046 | 0.86 | KAT2B (0.61) | P4HBTGM2DTYMKKAT2BEP300 | |
| SCHEMBL22056075 | 0.82 | KAT2B (0.54) | P4HBTGM2DTYMKKAT2BEP300 | |
| SCHEMBL17948274 | 0.81 | P4HB (1.00) | P4HBTGM2DTYMKKAT2BKAT2A | |
| SCHEMBL22056076 | 0.81 | P4HB (0.58) | P4HB | |
| SCHEMBL20022718 | 0.81 | P4HB (0.70) | P4HBTGM2 | |
| SCHEMBL22056078 | 0.81 | KAT2B (0.50) | P4HBTGM2DTYMKKAT2BEP300 | |
| SCHEMBL20022721 | 0.78 | P4HB (0.69) | P4HBTGM2 | |
| SCHEMBL22056074 | 0.77 | KAT2B (0.72) | TGM2DTYMKKAT2BEP300CREBBP | |
| SCHEMBL22056077 | 0.76 | KAT2B (0.69) | DTYMKKAT2BEP300CREBBPKAT2A | |
| SCHEMBL20022720 | 0.75 | P4HB (0.65) | P4HBTGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180092908-A1 | SMALL MOLECULE OXIDIZERS OF PDI AND THEIR USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-04-05 | — | — | US | disclosed |
| US-20180092908-A1 | SMALL MOLECULE OXIDIZERS OF PDI AND THEIR USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180092908-A1 | SMALL MOLECULE OXIDIZERS OF PDI AND THEIR USE | PDIA5, PDIA4, PDIA6 | P4HB 5/4885TGM2 2410/4885DTYMK 2784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.