Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.48 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1412268 | 0.76 | ALDH1A1 (0.48) | KDM4EMAPTALDH1A1LMNAHTT | |
| SCHEMBL9455748 | 0.73 | ALDH1A1 (0.50) | KDM4EMAPTALDH1A1LMNAHTT | |
| SCHEMBL6232605 | 0.72 | ALDH1A1 (0.48) | KDM4EMAPTALDH1A1LMNAHTT | |
| SCHEMBL20022717 | 0.72 | KDM4E (0.48) | KDM4EMAPTALDH1A1LMNAHTT | |
| SCHEMBL25871160 | 0.70 | HDAC3 (0.43) | KDM4EALDH1A1LMNAHTTPARP1 | |
| SCHEMBL292306 | 0.68 | ALDH1A1 (0.41) | KDM4EMAPTALDH1A1LMNAHTT | |
| SCHEMBL26476547 | 0.68 | KDM4E (0.47) | KDM4EALDH1A1LMNAHTTPARP1 | |
| SCHEMBL31288017 | 0.68 | CA1 (0.44) | KDM4EMAPTALDH1A1LMNAHTT | |
| SCHEMBL4213640 | 0.66 | PARP1 (0.65) | KDM4EMAPTPARP1SMN1; SMN2HSD17B10 | |
| SCHEMBL26078 | 0.66 | ALDH1A1 (1.00) | KDM4EMAPTALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180092908-A1 | SMALL MOLECULE OXIDIZERS OF PDI AND THEIR USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-04-05 | — | — | US | disclosed |
| US-20180092908-A1 | SMALL MOLECULE OXIDIZERS OF PDI AND THEIR USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180092908-A1 | SMALL MOLECULE OXIDIZERS OF PDI AND THEIR USE | PDIA5, PDIA4, PDIA6 | KDM4E 4750/4885MAPT 183/4885ALDH1A1 1489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.