Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | GLA | P06280 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | CFD | P00746 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31606608 | 0.85 | ALDH1A1 (0.44) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL15024931 | 0.85 | ALDH1A1 (0.44) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL10614221 | 0.84 | MAOA (0.54) | GAAMAOATDP1KDM5ACDK5 | |
| SCHEMBL589935 | 0.76 | KDM4E (0.52) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL8691721 | 0.74 | ERCC5 (0.54) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL18018247 | 0.74 | HCAR2 (0.45) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL29755033 | 0.73 | KDM5A (0.51) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL11768528 | 0.73 | KDM5A (0.51) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL9768431 | 0.72 | MAP3K11 (0.49) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL12849391 | 0.72 | MAOA (0.52) | KDM4EALDH1A1GLAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960548-B2 | Keratinocyte growth factor receptor—tyrosine specific inhibitors for the prevention of cancer metastatis | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-06-14 | — | — | US | disclosed |
| US-7960548-B2 | Keratinocyte growth factor receptor—tyrosine specific inhibitors for the prevention of cancer metastatis | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-06-14 | — | — | US | disclosed |
| US-20070078176-A1 | Keratinocyte growth factor receptor-tyrosine specific inhibitors for the prevention of cancer metastatis | US ARMY, SECRETARY OF THE ARMY | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078176-A1 | Keratinocyte growth factor receptor-tyrosine specific inhibitors for the prevention of cancer metastatis | FGFR1, FGFR3, MET | KDM4E 2093/4885ALDH1A1 1697/4885GLA 704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.