Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 7/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002572 | 0.93 | HSD17B10 (0.36) | MEN1KMT2APTGES2ALOX5ALOX5AP | |
| SCHEMBL2006486 | 0.93 | PTGES2 (0.41) | FAAHMEN1HTTKMT2APTGES2 | |
| SCHEMBL2008461 | 0.91 | RET (0.36) | FAAHMEN1KMT2ACYP2C9HSD17B10 | |
| SCHEMBL2002922 | 0.91 | MAPT (0.35) | MEN1HTTKMT2AALOX5ALOX5AP | |
| SCHEMBL2001677 | 0.91 | PTGES2 (0.43) | FAAHMEN1HTTKMT2APTGES2 | |
| SCHEMBL2000833 | 0.90 | KMT2A (0.42) | MEN1KMT2AALOX5ALOX5APCYP2C9 | |
| SCHEMBL2002667 | 0.89 | MEN1 (0.42) | FAAHMEN1HTTKMT2AALOX5 | |
| SCHEMBL1999358 | 0.89 | FAAH (0.41) | FAAHMEN1HTTKMT2APTGES2 | |
| SCHEMBL2007194 | 0.88 | ALOX5AP (0.42) | ALOX5ALOX5AP | |
| SCHEMBL2006154 | 0.88 | DRD2 (0.37) | MEN1KMT2APTGES2CYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |