Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002572 | 0.91 | HSD17B10 (0.36) | SRPK1PTGES2S1PR3ALDH1A1KDM4E | |
| SCHEMBL2001534 | 0.91 | HDAC6 (0.41) | DRD2PTGES2ALDH1A1LMNAKDM4E | |
| SCHEMBL2012645 | 0.90 | LMNA (0.40) | SRPK1ALDH1A1LMNAMEN1POLB | |
| SCHEMBL2002922 | 0.89 | MAPT (0.35) | SRPK1S1PR3ALDH1A1LMNAKDM4E | |
| SCHEMBL2006095 | 0.88 | FAAH (0.39) | DRD2SRPK1PTGES2KDM4EMEN1 | |
| SCHEMBL2005678 | 0.88 | STAT3 (0.35) | PTGES2ALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL2007743 | 0.88 | DRD2 (0.40) | DRD2PTGES2S1PR3ALDH1A1LMNA | |
| SCHEMBL2004407 | 0.87 | FAAH (0.40) | PTGES2S1PR3ALDH1A1LMNAKDM4E | |
| SCHEMBL2009136 | 0.87 | MAPT (0.40) | DRD2PTGES2MEN1KMT2ACYP3A4 | |
| SCHEMBL2000833 | 0.86 | KMT2A (0.42) | ALDH1A1LMNAKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |