Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | PRKDC | P78527 | 3/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19537967 | 0.89 | ALOX5 (0.39) | ALOX5PRKDCPIM1CSNK2A2CSNK2B | |
| SCHEMBL20030008 | 0.88 | KDM4E (0.42) | PRKDCPIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL20029869 | 0.88 | KDM4E (0.42) | PRKDCPIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL20029896 | 0.88 | ALOX5 (0.39) | ALOX5PRKDCPIM1CSNK2A2CSNK2B | |
| SCHEMBL20029856 | 0.87 | ALOX5 (0.38) | ALOX5PRKDCPIM1CSNK2A2CSNK2B | |
| SCHEMBL20030004 | 0.87 | SMN1; SMN2 (0.34) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL10331642 | 0.86 | ALOX5 (0.49) | ALOX5PRKDCPIM1CSNK2A2CSNK2B | |
| SCHEMBL10165772 | 0.86 | ALOX5 (0.49) | ALOX5PRKDCKDM4EATML3MBTL1 | |
| SCHEMBL9881128 | 0.86 | ALOX5 (0.49) | ALOX5PRKDCPIM1CSNK2A2CSNK2B | |
| SCHEMBL20024239 | 0.85 | KDM4E (0.35) | PRKDCPIM1CSNK2A2CSNK2BPIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030890-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | MERCK PATENT GMBH (DE) | 2024-07-09 | — | — | US | disclosed |
| US-12030890-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | MERCK PATENT GMBH (DE) | 2024-07-09 | — | — | US | disclosed |
| US-11530224-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | MERCK PATENT GMBH (DE) | 2022-12-20 | — | — | US | disclosed |
| EP-3519417-B1 | COMPOUNDS WITH DIAZADIBENZOFURANE OR DIAZADIBENZOTHIOPHENE STRUCTURES | MERCK PATENT GMBH (DE) | 2021-09-08 | — | — | EP | disclosed |
| WO-2018060307-A1 | COMPOUNDS WITH DIAZADIBENZOFURANE OR DIAZADIBENZOTHIOPHENE STRUCTURES | MERCK PATENT GMBH (DE) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030890-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | DDT, ESD, DBF4 | ALOX5 706/4885PRKDC 869/4885PIM1 344/4885 |
| US-11530224-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | DDT, ESD, DBF4 | ALOX5 706/4885PRKDC 869/4885PIM1 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.