Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.32 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.32 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20030009 | 0.96 | PIM1 (0.33) | SMN1; SMN2LMNAKDM4EATML3MBTL1 | |
| SCHEMBL20029869 | 0.90 | KDM4E (0.42) | SMN1; SMN2LMNAKDM4EATML3MBTL1 | |
| SCHEMBL20030008 | 0.90 | KDM4E (0.42) | SMN1; SMN2LMNAKDM4EATML3MBTL1 | |
| SCHEMBL19537964 | 0.89 | KDM4E (0.34) | SMN1; SMN2LMNAKDM4EATML3MBTL1 | |
| SCHEMBL20024786 | 0.87 | KDM4E (0.39) | SMN1; SMN2LMNAKDM4EATML3MBTL1 | |
| SCHEMBL20030007 | 0.87 | L3MBTL1 (0.39) | SMN1; SMN2LMNAKDM4EATML3MBTL1 | |
| SCHEMBL20030006 | 0.87 | ALOX5 (0.39) | SMN1; SMN2LMNAKDM4EATML3MBTL1 | |
| SCHEMBL21736372 | 0.87 | PIM1 (0.34) | SMN1; SMN2LMNAKDM4EATML3MBTL1 | |
| SCHEMBL19537970 | 0.86 | KDM4E (0.32) | KDM4EATML3MBTL1NPY5R | |
| SCHEMBL20024233 | 0.85 | L3MBTL1 (0.40) | SMN1; SMN2LMNAKDM4EATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030890-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | MERCK PATENT GMBH (DE) | 2024-07-09 | — | — | US | disclosed |
| US-12030890-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | MERCK PATENT GMBH (DE) | 2024-07-09 | — | — | US | disclosed |
| US-11530224-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | MERCK PATENT GMBH (DE) | 2022-12-20 | — | — | US | disclosed |
| EP-3519417-B1 | COMPOUNDS WITH DIAZADIBENZOFURANE OR DIAZADIBENZOTHIOPHENE STRUCTURES | MERCK PATENT GMBH (DE) | 2021-09-08 | — | — | EP | disclosed |
| WO-2018060307-A1 | COMPOUNDS WITH DIAZADIBENZOFURANE OR DIAZADIBENZOTHIOPHENE STRUCTURES | MERCK PATENT GMBH (DE) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030890-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | DDT, ESD, DBF4 | SMN1; SMN2 4234/4885LMNA 4452/4885KDM4E 1004/4885 |
| US-11530224-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | DDT, ESD, DBF4 | SMN1; SMN2 4234/4885LMNA 4452/4885KDM4E 1004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.