Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 9/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002250 | 0.93 | PLA2G2A (0.43) | ALOX5APALOX5CYP3A4CYP2C9MAPT | |
| SCHEMBL2006974 | 0.92 | LMNA (0.38) | ALOX5APCYP2C9MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2007957 | 0.90 | FAAH (0.42) | ALOX5APCYP3A4MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2011061 | 0.90 | ALOX5AP (0.39) | ALOX5APALOX5CYP3A4CYP2C9MAPT | |
| SCHEMBL2003154 | 0.90 | ALOX5AP (0.42) | ALOX5APALOX5MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2006918 | 0.89 | FAAH (0.44) | ALOX5APMAPTKMT2AFAAHCES1 | |
| SCHEMBL2002817 | 0.88 | FAAH (0.40) | ALOX5APALOX5CYP3A4CYP2C9MAPT | |
| SCHEMBL2003734 | 0.87 | ALOX5AP (0.42) | ALOX5APALOX5CYP3A4CYP2C9MAPT | |
| SCHEMBL2006169 | 0.86 | FAAH (0.43) | CYP3A4CYP2C9KMT2AFAAHCES1 | |
| SCHEMBL2002167 | 0.86 | ALOX5AP (0.43) | ALOX5APALOX5CYP3A4CYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |