Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003734 | 0.93 | ALOX5AP (0.42) | ALOX5APS1PR1S1PR5PTGS1PTGS2 | |
| SCHEMBL2001661 | 0.92 | PLA2G2A (0.48) | PTGS2PLA2G2AMAPTKMT2A | |
| SCHEMBL2003533 | 0.91 | S1PR1 (0.44) | ALOX5APS1PR1ALOX5MAPTKMT2A | |
| SCHEMBL2007918 | 0.91 | ALOX5AP (0.40) | ALOX5APS1PR1S1PR5MAPTSMN1; SMN2 | |
| SCHEMBL2008218 | 0.90 | ALOX5AP (0.41) | ALOX5APS1PR1S1PR5PTGS1PTGS2 | |
| SCHEMBL2003080 | 0.90 | ALOX5AP (0.41) | ALOX5APPTGS1PTGS2ALOX5MAPT | |
| SCHEMBL1999518 | 0.89 | MAPT (0.43) | S1PR1S1PR5MAPTKMT2A | |
| SCHEMBL2003586 | 0.87 | KMT2A (0.42) | ALOX5MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2001735 | 0.86 | MAPT (0.42) | S1PR1S1PR5PLA2G2AMAPTKMT2A | |
| SCHEMBL2011061 | 0.85 | ALOX5AP (0.39) | ALOX5APPTGS1PTGS2ALOX5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |