Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007957 | 0.93 | FAAH (0.42) | FAAHMEN1KMT2ACES1MAPT | |
| SCHEMBL2003537 | 0.91 | GRM5 (0.38) | FAAHMEN1KMT2AHTTCES1 | |
| SCHEMBL2002817 | 0.91 | FAAH (0.40) | FAAHMEN1KMT2ACES1MAPT | |
| SCHEMBL2006169 | 0.89 | FAAH (0.43) | FAAHMEN1KMT2ACES1MCL1 | |
| SCHEMBL2002250 | 0.89 | PLA2G2A (0.43) | FAAHMEN1KMT2AMAPTALOX5AP | |
| SCHEMBL2002486 | 0.89 | FAAH (0.43) | FAAHMEN1KMT2AHTTMAPT | |
| SCHEMBL2003080 | 0.89 | ALOX5AP (0.41) | FAAHKMT2ACES1MAPTALOX5AP | |
| SCHEMBL2003586 | 0.88 | KMT2A (0.42) | FAAHMEN1KMT2AHTTMAPT | |
| SCHEMBL1999092 | 0.88 | L3MBTL1 (0.42) | FAAHMEN1KMT2AHTTCES1 | |
| SCHEMBL2002667 | 0.85 | MEN1 (0.42) | FAAHMEN1KMT2AHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |