Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005116 | 0.93 | LMNA (0.42) | EDNRBSMN1; SMN2LMNAALDH1A1TP53 | |
| SCHEMBL2000432 | 0.93 | PLA2G2A (0.42) | SMN1; SMN2LMNAALDH1A1TP53KDM4E | |
| SCHEMBL2006961 | 0.92 | LMNA (0.40) | EDNRBSMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL2003946 | 0.90 | ALOX5AP (0.42) | SMN1; SMN2LMNAALDH1A1TP53KDM4E | |
| SCHEMBL2002744 | 0.90 | F2RL3 (0.40) | EDNRBSMN1; SMN2LMNAALDH1A1TP53 | |
| SCHEMBL2003641 | 0.90 | LMNA (0.41) | SMN1; SMN2LMNAALDH1A1TP53KDM4E | |
| SCHEMBL2011749 | 0.90 | LMNA (0.38) | EDNRBSMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL2003232 | 0.88 | LMNA (0.38) | SMN1; SMN2LMNAALDH1A1TP53KDM4E | |
| SCHEMBL2011328 | 0.87 | LMNA (0.40) | EDNRBSMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL2003998 | 0.87 | SLC26A4 (0.40) | EDNRBSMN1; SMN2LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |