Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 4/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999938 | 0.94 | PLA2G2A (0.39) | LMNASMN1; SMN2MAPTKDM4EFAAH | |
| SCHEMBL2003934 | 0.91 | KDM4E (0.39) | LMNAMAPTKDM4EFAAHCES1 | |
| SCHEMBL2008229 | 0.91 | ALOX5AP (0.40) | LMNASMN1; SMN2MAPTALOX5APALDH1A1 | |
| SCHEMBL2004340 | 0.91 | F2RL3 (0.37) | LMNASMN1; SMN2EDNRBMAPTALOX5AP | |
| SCHEMBL2003876 | 0.90 | SLC26A4 (0.35) | LMNASMN1; SMN2EDNRBMAPTALOX5AP | |
| SCHEMBL2003138 | 0.90 | EDNRB (0.41) | LMNASMN1; SMN2EDNRBMAPTALOX5AP | |
| SCHEMBL2004162 | 0.89 | OPRK1 (0.38) | LMNASMN1; SMN2MAPTKDM4EFAAH | |
| SCHEMBL2005259 | 0.88 | L3MBTL1 (0.41) | LMNAMAPTKDM4EFAAHCES1 | |
| SCHEMBL2002649 | 0.88 | LMNA (0.43) | LMNASMN1; SMN2MAPTKDM4EFAAH | |
| SCHEMBL2007246 | 0.88 | LMNA (0.38) | LMNASMN1; SMN2EDNRBMAPTALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |