Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EDNRB | P24530 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007346 | 0.93 | ALOX5AP (0.39) | LMNASMN1; SMN2EDNRBALOX5APSLC26A4 | |
| SCHEMBL2002932 | 0.93 | PLA2G2A (0.43) | LMNAEDNRBPLA2G2APOLBALDH1A1 | |
| SCHEMBL2006172 | 0.92 | ALOX5AP (0.39) | LMNASMN1; SMN2EDNRBALOX5APSLC26A4 | |
| SCHEMBL2004203 | 0.92 | ALOX5AP (0.45) | ALOX5APPLA2G2AALDH1A1KDM4EHPGD | |
| SCHEMBL1999686 | 0.91 | MAPT (0.42) | LMNASMN1; SMN2ALDH1A1HPGDRECQL | |
| SCHEMBL2005435 | 0.90 | F2RL3 (0.40) | LMNASMN1; SMN2EDNRBALOX5APPLA2G2A | |
| SCHEMBL2007246 | 0.90 | LMNA (0.38) | LMNASMN1; SMN2EDNRBALOX5APSLC26A4 | |
| SCHEMBL2008233 | 0.89 | LMNA (0.39) | LMNASMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL2005563 | 0.88 | LMNA (0.45) | LMNASMN1; SMN2ALOX5APPOLBALDH1A1 | |
| SCHEMBL2008306 | 0.88 | L3MBTL1 (0.43) | LMNASMN1; SMN2ALOX5APALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |