Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.42 |
| ▸ | PTGES | O14684 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999518 | 0.93 | MAPT (0.43) | KMT2AMEN1HTTPTGES2PTGES | |
| SCHEMBL2002667 | 0.92 | MEN1 (0.42) | KMT2AMEN1HTTFAAHDRD2 | |
| SCHEMBL2004165 | 0.90 | LMNA (0.38) | KMT2ALMNAMAPTALDH1A1KDM4E | |
| SCHEMBL2001735 | 0.90 | MAPT (0.42) | KMT2AMEN1PTGES2PTGESDRD2 | |
| SCHEMBL2006486 | 0.89 | PTGES2 (0.41) | KMT2AMEN1HTTPTGES2PTGES | |
| SCHEMBL2005851 | 0.89 | ALDH1A1 (0.43) | KMT2AMEN1HTTPTGES2DRD2 | |
| SCHEMBL2001661 | 0.89 | PLA2G2A (0.48) | KMT2AMEN1LMNAMAPTALDH1A1 | |
| SCHEMBL2006918 | 0.88 | FAAH (0.44) | KMT2AMEN1HTTFAAHMAPT | |
| SCHEMBL2003154 | 0.87 | ALOX5AP (0.42) | KMT2AMAPTSMN1; SMN2ALOX5 | |
| SCHEMBL2003864 | 0.84 | MAPT (0.38) | KMT2AMEN1FAAHDRD2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |