Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999518 | 0.93 | MAPT (0.43) | MAPTLMNAMEN1KMT2APTGES2 | |
| SCHEMBL1997410 | 0.92 | MAPT (0.36) | MAPTGAAPKMALDH1A1KDM4E | |
| SCHEMBL2005201 | 0.90 | L3MBTL1 (0.43) | MAPTGAAPKMALDH1A1KDM4E | |
| SCHEMBL2003586 | 0.90 | KMT2A (0.42) | MAPTGAAALDH1A1KDM4ELMNA | |
| SCHEMBL2005851 | 0.89 | ALDH1A1 (0.43) | MAPTALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL2002832 | 0.89 | S1PR3 (0.40) | MAPTGAAPKMALDH1A1KDM4E | |
| SCHEMBL2002817 | 0.88 | FAAH (0.40) | MAPTGAAPKMALDH1A1KDM4E | |
| SCHEMBL2001661 | 0.88 | PLA2G2A (0.48) | MAPTPKMALDH1A1LMNAMEN1 | |
| SCHEMBL2003154 | 0.86 | ALOX5AP (0.42) | MAPTKMT2APLA2G2AS1PR1S1PR5 | |
| SCHEMBL2003864 | 0.85 | MAPT (0.38) | MAPTALDH1A1KDM4ELMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |