Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | EDNRB | P24530 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005122 | 0.93 | S1PR1 (0.38) | ALOX5APLMNASMN1; SMN2EDNRBMAPT | |
| SCHEMBL2007043 | 0.92 | PLA2G2A (0.42) | ALOX5APLMNAMAPTALDH1A1MAPK1 | |
| SCHEMBL2004267 | 0.92 | S1PR1 (0.42) | ALOX5APLMNASMN1; SMN2MAPTNTRK1 | |
| SCHEMBL2003154 | 0.91 | ALOX5AP (0.42) | ALOX5APSMN1; SMN2MAPTNTRK1S1PR1 | |
| SCHEMBL2009008 | 0.90 | LMNA (0.41) | LMNASMN1; SMN2MAPTALDH1A1NPSR1 | |
| SCHEMBL2006974 | 0.90 | LMNA (0.38) | ALOX5APLMNASMN1; SMN2EDNRBMAPT | |
| SCHEMBL2004165 | 0.88 | LMNA (0.38) | ALOX5APLMNASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2005201 | 0.87 | L3MBTL1 (0.43) | ALOX5APLMNASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2002777 | 0.86 | LMNA (0.45) | LMNASMN1; SMN2MAPTALDH1A1NPSR1 | |
| SCHEMBL2002148 | 0.86 | LMNA (0.34) | ALOX5APLMNASMN1; SMN2EDNRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |