Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.31 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005062 | 0.95 | EPHX2 (0.33) | L3MBTL1EPHX2LMNAALDH1A1MAPT | |
| SCHEMBL2005516 | 0.92 | FAAH (0.33) | EPHX2LMNASCDSCD5RORC | |
| SCHEMBL2007450 | 0.91 | LMNA (0.38) | EPHX2LMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2002296 | 0.91 | MAPT (0.33) | LMNAALDH1A1MAPTSCDSCD5 | |
| SCHEMBL2003162 | 0.91 | PLA2G2A (0.37) | L3MBTL1LMNAALDH1A1MAPTTP53 | |
| SCHEMBL2005642 | 0.90 | GRM5 (0.39) | L3MBTL1EPHX2LMNAALDH1A1MAPT | |
| SCHEMBL2004749 | 0.90 | L3MBTL1 (0.36) | L3MBTL1LMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2002547 | 0.89 | RAB9A (0.39) | L3MBTL1EPHX2LMNAALDH1A1MAPT | |
| SCHEMBL2002732 | 0.89 | LMNA (0.33) | LMNAMAPTSMN1; SMN2 | |
| SCHEMBL2002081 | 0.87 | L3MBTL1 (0.35) | L3MBTL1EPHX2LMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |