Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037557 | 0.82 | LTA4H (0.42) | POLBLTA4HMEN1KMT2AATM | |
| SCHEMBL20038437 | 0.82 | LTA4H (0.42) | POLBLTA4HMEN1KMT2AATM | |
| SCHEMBL20249393 | 0.81 | RET (0.44) | POLBLTA4HMEN1KMT2AATM | |
| SCHEMBL26944345 | 0.81 | KMT2A (0.46) | POLBMEN1KMT2AATMHRH1 | |
| SCHEMBL1666554 | 0.81 | ALDH1A1 (0.61) | POLBMEN1KMT2AATMHRH1 | |
| SCHEMBL14308131 | 0.81 | LMNA (0.54) | MEN1KMT2AATMALDH1A1LMNA | |
| SCHEMBL4554100 | 0.80 | CHRNB2 (0.56) | ALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL12049097 | 0.80 | CHRNB2 (0.51) | MEN1KMT2AATMHRH1ALDH1A1 | |
| SCHEMBL27306249 | 0.80 | KMT2A (0.44) | POLBMEN1KMT2AATMHRH1 | |
| SCHEMBL12334539 | 0.79 | HRH3 (0.59) | MEN1KMT2AALDH1A1CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |