Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | VDR | P11473 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009008 | 0.94 | LMNA (0.41) | LMNASMN1; SMN2MAPTNPSR1TSHR | |
| SCHEMBL2004301 | 0.92 | RAB9A (0.36) | LMNASMN1; SMN2MAPTTSHRALDH1A1 | |
| SCHEMBL2004109 | 0.91 | LMNA (0.36) | LMNASMN1; SMN2MAPTNPSR1TSHR | |
| SCHEMBL2005201 | 0.90 | L3MBTL1 (0.43) | LMNASMN1; SMN2MAPTNPSR1TSHR | |
| SCHEMBL2003586 | 0.90 | KMT2A (0.42) | LMNASMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL2002777 | 0.90 | LMNA (0.45) | LMNASMN1; SMN2MAPTNPSR1TSHR | |
| SCHEMBL2007043 | 0.89 | PLA2G2A (0.42) | LMNAMAPTTSHRALDH1A1CYP1A2 | |
| SCHEMBL2003537 | 0.88 | GRM5 (0.38) | LMNASMN1; SMN2MAPTNPSR1TSHR | |
| SCHEMBL2007918 | 0.88 | ALOX5AP (0.40) | LMNASMN1; SMN2MAPTNPSR1ALDH1A1 | |
| SCHEMBL1999738 | 0.86 | CYP2C9 (0.39) | LMNASMN1; SMN2MAPTNPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |