Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042752 | 0.89 | HPGD (0.47) | TP53HPGDMAPTLMNAALDH1A1 | |
| SCHEMBL20042886 | 0.89 | HPGD (0.49) | GPR6HPGDKMT2AP2RX7TSHR | |
| SCHEMBL20042911 | 0.89 | P2RX7 (0.39) | GPR6TP53HPGDLRRK2MAPT | |
| SCHEMBL20042765 | 0.89 | P2RX7 (0.42) | GPR6HPGDLRRK2MALT1P2RX7 | |
| SCHEMBL20042700 | 0.87 | TSHR (0.40) | TP53HPGDLRRK2MAPTLMNA | |
| SCHEMBL20042667 | 0.86 | TACR3 (0.46) | P2RX7 | |
| SCHEMBL20042887 | 0.86 | GPR6 (0.42) | GPR6TP53HPGDMAPTALDH1A1 | |
| SCHEMBL20042733 | 0.84 | MEN1 (0.41) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL20042792 | 0.84 | TACR3 (0.46) | GPR6TP53HPGDMAPTMEN1 | |
| SCHEMBL20042880 | 0.83 | P2RX7 (0.40) | HPGDLRRK2MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |