Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.42 |
| ▸ | GPR6 | P46095 | 3/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042780 | 0.90 | P2RX7 (0.43) | P2RX7GPR6MAPK7MGLLEPHX2 | |
| SCHEMBL20042680 | 0.89 | GPR6 (0.44) | P2RX7GPR6MALT1LRRK2HPGD | |
| SCHEMBL20042694 | 0.88 | P2RX7 (0.43) | P2RX7GPR6MAPK7MGLLLRRK2 | |
| SCHEMBL20042911 | 0.87 | P2RX7 (0.39) | P2RX7GPR6LRRK2HPGDKCNH2 | |
| SCHEMBL20042752 | 0.85 | HPGD (0.47) | P2RX7HPGD | |
| SCHEMBL20042886 | 0.85 | HPGD (0.49) | P2RX7GPR6HPGD | |
| SCHEMBL20042667 | 0.85 | TACR3 (0.46) | P2RX7KCNH2 | |
| SCHEMBL20042705 | 0.85 | EPHX2 (0.45) | P2RX7MAPK7MGLLEPHX2 | |
| SCHEMBL20042792 | 0.83 | TACR3 (0.46) | P2RX7GPR6HPGDKCNH2 | |
| SCHEMBL20042887 | 0.83 | GPR6 (0.42) | P2RX7GPR6HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |