Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 11/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042754 | 0.92 | MEN1 (0.41) | KDM1ACYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL20042666 | 0.89 | KMT2A (0.46) | MEN1KMT2AP2RX7GRM5 | |
| SCHEMBL20042733 | 0.88 | MEN1 (0.41) | MEN1KMT2AP2RX7KDM4EHPGD | |
| SCHEMBL20042903 | 0.88 | MEN1 (0.42) | MEN1KMT2AP2RX7KDM4EHPGD | |
| SCHEMBL20042823 | 0.88 | P2RX7 (0.45) | MEN1KMT2AP2RX7HPGDTSHR | |
| SCHEMBL20042821 | 0.86 | MEN1 (0.41) | MEN1KMT2AP2RX7KDM4EHPGD | |
| SCHEMBL20042792 | 0.86 | TACR3 (0.46) | MEN1KMT2AP2RX7HPGD | |
| SCHEMBL20042836 | 0.86 | P2RX7 (0.43) | MEN1KMT2AP2RX7HPGDTSHR | |
| SCHEMBL20042698 | 0.85 | MEN1 (0.43) | MEN1KMT2AP2RX7KDM4EHPGD | |
| SCHEMBL20042728 | 0.85 | MEN1 (0.42) | MEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |