Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042756 | 0.89 | P2RX7 (0.38) | HSP90AA1P2RX7 | |
| SCHEMBL20042769 | 0.88 | P2RX7 (0.38) | HSP90AA1P2RX7 | |
| SCHEMBL20042752 | 0.85 | HPGD (0.47) | P2RX7 | |
| SCHEMBL20042886 | 0.85 | HPGD (0.49) | P2RX7 | |
| SCHEMBL20042674 | 0.84 | P2RX7 (0.37) | HSP90AA1P2RX7 | |
| SCHEMBL20042689 | 0.84 | P2RX7 (0.39) | GRM5HSP90AA1P2RX7 | |
| SCHEMBL20042700 | 0.83 | TSHR (0.40) | HSP90AA1P2RX7 | |
| SCHEMBL20042667 | 0.82 | TACR3 (0.46) | P2RX7 | |
| SCHEMBL20042887 | 0.82 | GPR6 (0.42) | P2RX7 | |
| SCHEMBL20042755 | 0.82 | GRM5 (0.43) | GRM5P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |