Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 4/20 | 0.35 |
| ▸ | CNR1 | P21554 | 4/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 5/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042720 | 0.89 | GRM5 (0.41) | P2RX7HSP90AA1 | |
| SCHEMBL20042769 | 0.89 | P2RX7 (0.38) | P2RX7GPR55CNR1CNR2GBA1 | |
| SCHEMBL20042671 | 0.84 | P2RX7 (0.45) | P2RX7GPR55CNR1CNR2GBA1 | |
| SCHEMBL20042755 | 0.83 | GRM5 (0.43) | P2RX7GBA1KMT2ATSHRMEN1 | |
| SCHEMBL20042873 | 0.83 | P2RX7 (0.38) | P2RX7GPR55CNR1CNR2GBA1 | |
| SCHEMBL20042743 | 0.83 | P2RX7 (0.40) | P2RX7GPR55CNR1CNR2GBA1 | |
| SCHEMBL20042674 | 0.82 | P2RX7 (0.37) | P2RX7GBA1HSP90AA1KMT2AMEN1 | |
| SCHEMBL20042887 | 0.82 | GPR6 (0.42) | P2RX7GPR55CNR1CNR2GBA1 | |
| SCHEMBL20042836 | 0.82 | P2RX7 (0.43) | P2RX7GPR55CNR1CNR2GBA1 | |
| SCHEMBL20042872 | 0.81 | P2RX7 (0.44) | P2RX7GPR55CNR1CNR2GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |