Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042817 | 0.91 | PKM (0.44) | P2RX7GBA1SLC6A7 | |
| SCHEMBL20042751 | 0.88 | HSD17B10 (0.49) | HTTP2RX7TACR3KCNH2GBA1 | |
| SCHEMBL20042829 | 0.88 | P2RX7 (0.41) | HTTP2RX7TACR3KCNH2GBA1 | |
| SCHEMBL20042839 | 0.88 | P2RX7 (0.45) | HTTP2RX7L3MBTL1GBA1SMN1; SMN2 | |
| SCHEMBL20042704 | 0.88 | P2RX7 (0.50) | HTTP2RX7ABL1BCRCYP2C19 | |
| SCHEMBL20042666 | 0.88 | KMT2A (0.46) | P2RX7TACR3KCNH2GBA1HSD11B1 | |
| SCHEMBL20042823 | 0.87 | P2RX7 (0.45) | HTTP2RX7TACR3GBA1HSD11B1 | |
| SCHEMBL20042836 | 0.87 | P2RX7 (0.43) | HTTP2RX7TACR3GBA1SMN1; SMN2 | |
| SCHEMBL20042684 | 0.87 | SMN1; SMN2 (0.52) | HTTP2RX7ABL1BCRCYP2C19 | |
| SCHEMBL20042728 | 0.85 | MEN1 (0.42) | L3MBTL1GBA1EPHX2SLC6A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |