Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GBA1 | P04062 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042751 | 0.91 | HSD17B10 (0.49) | ALDH1A1GBA1MEN1KMT2AHPGD | |
| SCHEMBL20042685 | 0.91 | HTT (0.42) | GBA1P2RX7SLC6A7 | |
| SCHEMBL20042839 | 0.90 | P2RX7 (0.45) | ALDH1A1GBA1MEN1KMT2AHPGD | |
| SCHEMBL20042704 | 0.88 | P2RX7 (0.50) | ALDH1A1GBA1MEN1KMT2AHPGD | |
| SCHEMBL20042728 | 0.88 | MEN1 (0.42) | ALDH1A1GBA1MEN1KMT2ASLC6A7 | |
| SCHEMBL20042671 | 0.87 | P2RX7 (0.45) | ALDH1A1GBA1KMT2AHPGDP2RX7 | |
| SCHEMBL20042755 | 0.86 | GRM5 (0.43) | ALDH1A1GBA1MEN1KMT2AHPGD | |
| SCHEMBL20042668 | 0.86 | HPGD (0.51) | ALDH1A1GBA1MEN1KMT2AHPGD | |
| SCHEMBL20042776 | 0.86 | P2RX7 (0.41) | GBA1MEN1KMT2AP2RX7KDM4E | |
| SCHEMBL20042743 | 0.85 | P2RX7 (0.40) | GBA1HPGDP2RX7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |