Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ME2 | P23368 | 2/20 | 0.43 |
| ▸ | ME1 | P48163 | 2/20 | 0.43 |
| ▸ | ME3 | Q16798 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042730 | 0.88 | NPC1 (0.48) | NPC1TDP1L3MBTL1GPBAR1FKBP1A | |
| SCHEMBL20042748 | 0.83 | NPC1 (0.49) | NPC1TDP1L3MBTL1GPBAR1FKBP1A | |
| SCHEMBL20042690 | 0.73 | GFER (0.41) | NPC1TDP1L3MBTL1GPBAR1GFER | |
| SCHEMBL16210173 | 0.72 | TMEM97 (0.52) | — | |
| SCHEMBL20042688 | 0.72 | C3AR1 (0.45) | POLBKMT2A | |
| SCHEMBL20042830 | 0.72 | ME2 (0.43) | NPC1TDP1GPBAR1FKBP1AME2 | |
| SCHEMBL20042703 | 0.69 | PTGDR2 (0.37) | — | |
| SCHEMBL7131839 | 0.69 | NPC1 (0.86) | NPC1TDP1L3MBTL1FKBP1APOLB | |
| SCHEMBL8413071 | 0.67 | NPC1 (0.61) | NPC1TDP1L3MBTL1FKBP1APOLB | |
| SCHEMBL25432319 | 0.66 | NPC1 (0.93) | NPC1TDP1L3MBTL1FKBP1APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |