Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RGS12 | O14924 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999823 | 0.93 | F2RL3 (0.36) | F2RL3CYP3A4CYP2C9CYP1A2CYP2D6 | |
| SCHEMBL2004514 | 0.93 | F2RL3 (0.39) | PLA2G2APTGS2F2RL3CYP3A4CYP2C9 | |
| SCHEMBL2006841 | 0.92 | CYP3A4 (0.37) | CYP3A4CYP2C9CYP1A2CYP2D6MAPT | |
| SCHEMBL2001047 | 0.92 | PLA2G2A (0.37) | PLA2G2APTGS2F2RL3CYP3A4CYP2C9 | |
| SCHEMBL1998915 | 0.91 | LMNA (0.42) | PLA2G2APTGS2CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL2010346 | 0.91 | PLA2G2A (0.37) | PLA2G2APTGS2F2RL3CYP3A4CYP2C9 | |
| SCHEMBL2002947 | 0.90 | CYP3A4 (0.35) | CYP3A4CYP2C9PTGDR2TP53MAPT | |
| SCHEMBL2004240 | 0.90 | PLA2G2A (0.39) | PLA2G2ACYP3A4CYP2C9CYP1A2PTGDR2 | |
| SCHEMBL2005377 | 0.89 | L3MBTL1 (0.36) | CYP3A4CYP2C9MAPTGSK3BF10 | |
| SCHEMBL2000385 | 0.88 | FAAH (0.38) | PLA2G2AF2RL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |