Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC26A4 | O43511 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 4/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 2/20 | 0.31 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005382 | 0.94 | PLA2G2A (0.38) | SLC26A4POLBLMNAMAPTPLA2G2A | |
| SCHEMBL2003216 | 0.91 | LMNA (0.35) | LMNASMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL2008598 | 0.91 | ALOX5AP (0.40) | SLC26A4LMNASMN1; SMN2MAPTALOX5AP | |
| SCHEMBL2004327 | 0.91 | F2RL3 (0.34) | SLC26A4POLBLMNASMN1; SMN2MAPT | |
| SCHEMBL2011749 | 0.90 | LMNA (0.38) | SLC26A4POLBLMNASMN1; SMN2MAPT | |
| SCHEMBL2005116 | 0.90 | LMNA (0.42) | SLC26A4POLBLMNASMN1; SMN2MAPT | |
| SCHEMBL2002612 | 0.89 | FAAH (0.35) | LMNASMN1; SMN2MAPTTP53 | |
| SCHEMBL2006179 | 0.88 | L3MBTL1 (0.37) | LMNAMAPTCYP3A4CYP2C9 | |
| SCHEMBL2005115 | 0.88 | ALOX5AP (0.37) | SLC26A4POLBLMNASMN1; SMN2MAPT | |
| SCHEMBL2005952 | 0.88 | SLC26A4 (0.37) | SLC26A4POLBLMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |