Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20054023 | 0.75 | — | — | |
| SCHEMBL26549023 | 0.70 | NUDT1 (0.34) | — | |
| SCHEMBL27054804 | 0.68 | ROCK2 (0.39) | LRRK2 | |
| SCHEMBL20053916 | 0.67 | PDCD1 (0.44) | LRRK2 | |
| SCHEMBL27329663 | 0.66 | HTR2C (0.34) | LRRK2 | |
| SCHEMBL26552315 | 0.59 | ALDH1A1 (0.35) | LRRK2 | |
| SCHEMBL26036421 | 0.57 | ALDH1A1 (0.33) | LRRK2 | |
| SCHEMBL21652590 | 0.56 | MAP4K1 (0.34) | — | |
| SCHEMBL12918492 | 0.55 | — | — | |
| SCHEMBL27601711 | 0.54 | NOS3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357921-A2 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | Sunesis Pharmaceuticals, Inc. (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-3080103-B1 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | BIOGEN MA INC (US) | 2018-04-18 | — | — | EP | disclosed |