Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 2/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20056311 | 0.82 | ALDH1A1 (0.39) | LMNAKLK7KLK5ACHEPDE4D | |
| SCHEMBL20056422 | 0.82 | PDE4D (0.42) | LMNAACHEPDE4DBCHEPTPN1 | |
| SCHEMBL19861571 | 0.78 | BCHE (0.45) | ACHEBCHEPTPN1CDC25B | |
| SCHEMBL21697602 | 0.78 | LMNA (0.51) | LMNAACHEPDE4DBCHEPTPN1 | |
| SCHEMBL16010060 | 0.78 | LMNA (0.51) | LMNAACHEPDE4DBCHEPTPN1 | |
| SCHEMBL21218201 | 0.71 | LMNA (0.51) | LMNAACHEPDE4DBCHEPTPN1 | |
| SCHEMBL16076886 | 0.70 | NAAA (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1968853 | 0.69 | BUB1 (0.45) | LMNAACHEALDH1A1 | |
| SCHEMBL23047646 | 0.69 | PDE4D (0.52) | LMNAACHEPDE4DBCHE | |
| SCHEMBL29711913 | 0.69 | PDE4D (0.52) | LMNAACHEPDE4DBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970353-B1 | MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | VERTEX PHARMA (US) | 2018-04-18 | — | — | EP | disclosed |