Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311376 | 0.81 | ALDH1A1 (0.42) | ALDH1A1MAPTLMNAALOX15KMT2A | |
| SCHEMBL20458050 | 0.80 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAKMT2AMEN1 | |
| SCHEMBL12257108 | 0.80 | ALDH1A1 (0.56) | ALDH1A1MAPK1MAPTLMNAALOX15 | |
| SCHEMBL18338708 | 0.79 | NOS1 (0.48) | ALDH1A1MAPK1MAPTLMNAALOX15 | |
| SCHEMBL24166779 | 0.77 | MEN1 (0.46) | ALDH1A1MAPK1MAPTLMNAALOX15 | |
| SCHEMBL24166523 | 0.76 | ALDH1A1 (0.51) | ALDH1A1MAPK1MAPTLMNAALOX15 | |
| SCHEMBL4377344 | 0.76 | HDAC4 (0.48) | ALDH1A1MAPK1MAPTLMNAALOX15 | |
| SCHEMBL26757947 | 0.76 | ALDH1A1 (0.48) | ALDH1A1MAPK1MAPTLMNAKMT2A | |
| SCHEMBL1696796 | 0.75 | HTR1A (0.45) | ALOX15HSD17B10RAB9ASMN1; SMN2BRD4 | |
| SCHEMBL14491916 | 0.75 | SIGMAR1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3309146-A1 | SULFONAMIDE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF | University of Tsukuba (JP) | 2018-04-18 | — | — | EP | disclosed |