Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 9/20 | 0.41 |
| ▸ | PTGES | O14684 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009136 | 0.93 | MAPT (0.40) | PTGES2PTGESKMT2AMEN1TBXAS1 | |
| SCHEMBL2006095 | 0.93 | FAAH (0.39) | PTGES2PTGESKMT2AMEN1HTT | |
| SCHEMBL2001677 | 0.91 | PTGES2 (0.43) | PTGES2PTGESKMT2AMEN1HTT | |
| SCHEMBL2002832 | 0.91 | S1PR3 (0.40) | PTGES2PTGESKMT2AMEN1TBXAS1 | |
| SCHEMBL2004953 | 0.90 | PLA2G2A (0.45) | KMT2AMEN1LMNA | |
| SCHEMBL2003586 | 0.89 | KMT2A (0.42) | PTGES2PTGESKMT2AMEN1HTT | |
| SCHEMBL2008218 | 0.88 | ALOX5AP (0.41) | — | |
| SCHEMBL2002572 | 0.85 | HSD17B10 (0.36) | PTGES2PTGESKMT2AMEN1PPARG | |
| SCHEMBL1999358 | 0.85 | FAAH (0.41) | PTGES2PTGESKMT2AMEN1HTT | |
| SCHEMBL2010143 | 0.85 | PTGES2 (0.42) | PTGES2PTGESKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |