Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | EED | O75530 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22645751 | 0.79 | CYP1A2 (0.38) | CYP2A6CYP1A2CA2ALDH1A1KIF11 | |
| SCHEMBL22645752 | 0.79 | CA2 (0.33) | CA2KIF11PSMB5PSMB8POLB | |
| SCHEMBL22645749 | 0.78 | CA2 (0.36) | GABRA1GABRB2CA2ALDH1A1KIF11 | |
| SCHEMBL2607400 | 0.77 | CYP2A6 (0.48) | CYP2A6CYP1A2CES1MCL1CA2 | |
| SCHEMBL25451226 | 0.77 | GABRA1 (0.42) | GABRA1GABRB2CYP2A6CYP1A2CES1 | |
| SCHEMBL22645760 | 0.77 | SMN1; SMN2 (0.46) | MCL1ALDH1A1PSMB5SMN1; SMN2POLB | |
| SCHEMBL22645753 | 0.74 | TP53 (0.31) | SMN1; SMN2POLB | |
| SCHEMBL16185334 | 0.73 | GABRA1 (0.47) | GABRA1GABRB2CYP2A6CYP1A2ELANE | |
| SCHEMBL19099779 | 0.72 | CYP2A6 (0.42) | CYP2A6CYP1A2CES1MCL1CA2 | |
| SCHEMBL22645758 | 0.72 | MAPT (0.40) | GABRA1GABRB2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858951-B2 | Boronic acid derivatives | MERCK PATENT GMBH (DE) | 2024-01-02 | — | — | US | disclosed |
| US-20230321049-A1 | COMPOSITIONS OF ENPP1 INHIBITORS AND USES THEREOF | Petragen, Inc. | 2023-10-12 | — | — | US | disclosed |
| US-20230321049-A1 | COMPOSITIONS OF ENPP1 INHIBITORS AND USES THEREOF | Petragen, Inc. | 2023-10-12 | — | — | US | disclosed |
| US-20180179231-A1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-06-28 | — | — | US | disclosed |
| US-20180179232-A1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-06-28 | — | — | US | disclosed |
| US-20180105539-A1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-04-19 | — | — | US | disclosed |
| US-20180105538-A1 | BORONIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105539-A1 | BORONIC ACID DERIVATIVES | BCL9, BCL9L, BCL6 | GABRA1 336/4885GABRB2 386/4885CYP2A6 1313/4885 |
| US-20180179231-A1 | BORONIC ACID DERIVATIVES | BCL9, BCL9L, BCL6 | GABRA1 336/4885GABRB2 386/4885CYP2A6 1313/4885 |
| US-20180105538-A1 | BORONIC ACID DERIVATIVES | BCL9, BCL9L, BCL6 | GABRA1 336/4885GABRB2 386/4885CYP2A6 1313/4885 |
| US-20230321049-A1 | COMPOSITIONS OF ENPP1 INHIBITORS AND USES THEREOF | ENPP1, ENPP2, ENPP3 | GABRA1 1741/4885GABRB2 1929/4885CYP2A6 4435/4885 |
| US-20180179232-A1 | BORONIC ACID DERIVATIVES | BCL9, BCL9L, BCL6 | GABRA1 336/4885GABRB2 386/4885CYP2A6 1313/4885 |
| US-11858951-B2 | Boronic acid derivatives | PSMB7, PSMA7, BRD7 | GABRA1 175/4885GABRB2 173/4885CYP2A6 3357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.