Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003216 | 0.95 | LMNA (0.35) | L3MBTL1LMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2002612 | 0.91 | FAAH (0.35) | L3MBTL1LMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2001923 | 0.90 | LMNA (0.41) | LMNAALDH1A1MAPTALOX12MAPK1 | |
| SCHEMBL2007820 | 0.90 | LMNA (0.37) | L3MBTL1LMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL2002081 | 0.90 | L3MBTL1 (0.35) | L3MBTL1LMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2005382 | 0.90 | PLA2G2A (0.38) | LMNAALDH1A1MAPTMAPK1TSHR | |
| SCHEMBL2005259 | 0.89 | L3MBTL1 (0.41) | L3MBTL1LMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2003876 | 0.88 | SLC26A4 (0.35) | LMNAMAPTCYP3A4CYP2C9 | |
| SCHEMBL2000320 | 0.88 | LMNA (0.46) | L3MBTL1LMNAALDH1A1MAPTALOX12 | |
| SCHEMBL2009971 | 0.87 | L3MBTL1 (0.37) | L3MBTL1LMNAALDH1A1MAPTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |