Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 8/20 | 0.47 |
| ▸ | REN | P00797 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PEPD | P12955 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434434 | 1.00 | FKBP1A (0.52) | FKBP1ARAB9AACERENLMNA | |
| SCHEMBL9650460 | 1.00 | FKBP1A (0.52) | FKBP1ARAB9AACERENLMNA | |
| SCHEMBL1774605 | 0.95 | FKBP1A (0.58) | FKBP1ARAB9AACERENLMNA | |
| SCHEMBL7551999 | 0.89 | FKBP1A (0.45) | FKBP1ARAB9AACERENLMNA | |
| SCHEMBL20253015 | 0.86 | FKBP1A (0.51) | FKBP1ARAB9AHSD17B10 | |
| SCHEMBL2006947 | 0.86 | FKBP1A (0.58) | FKBP1ARAB9ALMNAPEPDALDH1A1 | |
| SCHEMBL9169937 | 0.81 | RAB9A (0.61) | RAB9AACERENLMNAHSD17B10 | |
| SCHEMBL31257712 | 0.81 | RAB9A (0.61) | RAB9AACERENLMNAHSD17B10 | |
| SCHEMBL9169924 | 0.81 | RAB9A (0.61) | RAB9AACERENLMNAHSD17B10 | |
| SCHEMBL21296651 | 0.81 | RAB9A (0.54) | FKBP1ARAB9AACERENLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100145071-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GLIAMED, INC. (US) | 2010-06-10 | — | — | US | claimed |
| EP-1433781-B1 | Pyrrolidine carboxylic acid derivatives | MGI GP INC (US) | 2010-02-24 | — | — | EP | claimed |
| EP-1433781-A1 | Pyrrolidine carboxylic acid derivatives | GPI NIL Holdings, Inc. (US) | 2004-06-30 | — | — | EP | claimed |
| US-12161625-B2 | Substituted pyrrolizine compounds and uses thereof | GILEAD SCIENCES, INC. (US) | 2024-12-10 | — | — | US | disclosed |
| EP-3922634-B1 | SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF | GILEAD SCIENCES INC (US) | 2023-10-25 | — | — | EP | disclosed |
| EP-3922634-B1 | SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF | GILEAD SCIENCES INC (US) | 2023-10-25 | — | — | EP | disclosed |
| US-20230270719-A1 | SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF | GILEAD SCIENCES, INC. | 2023-08-31 | — | — | US | disclosed |
| US-20230270719-A1 | SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF | GILEAD SCIENCES, INC. | 2023-08-31 | — | — | US | disclosed |
| EP-3922634-A1 | SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF | Gilead Sciences, Inc. (US) | 2021-12-15 | — | — | EP | disclosed |
| EP-3922634-A1 | SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF | Gilead Sciences, Inc. (US) | 2021-12-15 | — | — | EP | disclosed |
| CN-113620960-A | Substituted pyrrolizine compounds and uses thereof | 吉利德科学公司 | 2021-11-09 | — | — | CN | disclosed |
| US-5859031-A | Small molecule inhibitors of rotamase enzyme activity | GPI NIL HOLDINGS, INC. (US) | 1999-01-12 | — | — | US | disclosed |
| US-5846979-A | N-oxides of heterocyclic esters, amides, thioesters, and ketones | GPI NIL HOLDINGS, INC. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5795908-A | FKBP IMMUNOPHILINS FOR ENZYME INHIBITORS | GPI NIL HOLDINGS, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| US-5786378-A | FKBP TYPE IMMUNOPHILLINS FOR NERVOUS SYSTEM DISORDERS | GPI NIL HOLDINGS, INC. (US) | 1998-07-28 | — | — | US | disclosed |
| EP-0769006-A4 | — | GUILFORD PHARM INC (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0769006-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1997-04-23 | — | — | EP | disclosed |
| US-5614547-A | Small molecule inhibitors of rotamase enzyme | GUILFORD PHARMACEUTICALS INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996040633-A9 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | — | 1997-02-27 | — | — | WO | disclosed |
| WO-1996040633-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1996-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145071-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | FKBP8, FKBP1A, FKBP2 | FKBP1A 2/4885RAB9A 1399/4885ACE 609/4885 |
| US-12161625-B2 | Substituted pyrrolizine compounds and uses thereof | HMBS, DHFR, HCCS | FKBP1A 346/4885RAB9A 3585/4885ACE 930/4885 |
| US-20230270719-A1 | SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF | HMBS, DHFR, HCCS | FKBP1A 346/4885RAB9A 3585/4885ACE 930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.