Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 9/20 | 0.57 |
| ▸ | NOS3 | P29474 | 6/20 | 0.57 |
| ▸ | NOS1 | P29475 | 6/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.33 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12161257 | 0.91 | NOS2 (0.43) | NOS2NOS3NOS1S1PR2CCR1 | |
| Hydrochloric Acid SCHEMBL18640616 | 0.88 | NOS2 (0.41) | NOS2NOS3NOS1S1PR2CCR1 | |
| SCHEMBL6464978 | 0.88 | NOS2 (0.70) | NOS2NOS3NOS1 | |
| SCHEMBL20072601 | 0.82 | ACHE (0.42) | NOS2NOS3CCR1KDM5B | |
| SCHEMBL26241406 | 0.80 | NOS3 (0.45) | NOS2NOS3NOS1CCR1KDM5B | |
| SCHEMBL18977860 | 0.80 | S1PR2 (0.43) | NOS2NOS3NOS1S1PR2CCR1 | |
| SCHEMBL18640608 | 0.80 | S1PR2 (0.37) | NOS2NOS3NOS1S1PR2CCR1 | |
| SCHEMBL667378 | 0.79 | NOS2 (0.44) | NOS2NOS3NOS1S1PR2CCR1 | |
| SCHEMBL10367813 | 0.77 | S1PR2 (0.38) | NOS2NOS3NOS1S1PR2CCR1 | |
| SCHEMBL13827864 | 0.77 | NOS2 (0.57) | NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11225469-B2 | Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2022-01-18 | — | — | US | disclosed |
| US-20180105508-A1 | INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11225469-B2 | Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof | PHGDH, PGD, PGK1 | NOS2 2906/4885NOS3 2640/4885NOS1 2616/4885 |
| US-20180105508-A1 | INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF | PHGDH, PGD, PGK1 | NOS2 2680/4885NOS3 2532/4885NOS1 2516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.