Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO2 | Q9NYQ3 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | BAD | Q92934 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.35 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20075637 | 0.82 | GABRA2 (0.43) | MAPTMAPK14MAPK1 | |
| SCHEMBL167755 | 0.76 | IRAK4 (0.39) | HAO2MAPTMAPK14 | |
| SCHEMBL4964605 | 0.75 | HAO2 (0.53) | HAO2CA12ALPLRPA1BCL2L1 | |
| SCHEMBL5255490 | 0.70 | MAPK14 (0.61) | HAO2MAPK14 | |
| SCHEMBL7646423 | 0.70 | HAO2 (0.49) | HAO2CA12ALPLRPA1MAPK14 | |
| SCHEMBL168203 | 0.70 | TUBB4A (0.43) | HAO2MAPTMAPK14 | |
| SCHEMBL20075544 | 0.70 | SLC34A1 (0.45) | — | |
| Water SCHEMBL5256024 | 0.69 | MAPK14 (0.59) | HAO2MAPK14 | |
| SCHEMBL10642212 | 0.69 | LMNA (0.44) | MAPTMAPK1MEN1KMT2A | |
| SCHEMBL1929469 | 0.68 | CA12 (0.49) | HAO2CA12ALPLRPA1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526212-B1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AG (DE) | 2021-12-22 | — | — | EP | disclosed |
| WO-2018069222-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2018-04-19 | — | — | WO | disclosed |